Eating mangoes helped relax blood vessels in as little as two hours, according to the study.
And some of the participants showed favourable changes in the production of breath methane, an indication of the potential influence on gut fermentation.
Lead researcher Doctor Robert Hackman, of the University of California, Davis, said: "This is the first study to demonstrate positive vascular effects of mango intake in humans.
"Our results build on previous animal and cell studies that point to the potential benefits of mangoes to promote health."
Mangoes contain a mix of polyphenols – including mangiferin, quercetin, gallotannins, and gallic acid – that have been the focus of previous investigations exploring the potential health-protecting properties of the fruit.
For the new study, 24 healthy postmenopausal women consumed 330 grams (two servings) of mango daily for 14 days.
The honey mango, or Ataulfo, was chosen for the study due to the high concentration of polyphenols in it.
After 14 days of eating mango, the study participants resumed their normal daily diet but eliminated mango intake for 13 days.
Measurements were taken during each visit, including heart rate and blood pressure, blood samples and breath samples, which are increasingly used in nutrition studies to evaluate gut health status.
At the start of the study, blood pressure was not significantly different between the study visits.
But once mango was consumed, systolic blood pressure was significantly lower two hours afterwards.
Pulse pressure was also significantly reduced two hours after eating mango, according to the researchers.
Systolic blood pressure - the upper number in blood pressure readings - indicates how much pressure your blood is exerting against your artery walls when the heart beats.
Pulse pressure is the difference between systolic and diastolic (bottom number) in blood pressure readings. Pulse pressure can be used as an indicator of heart health.
Breath levels of hydrogen and methane were measured, which reflect the amount of those gases that were produced due to microbial fermentation in the intestinal tract.
Dr Hackman said some study participants produced hydrogen, some produced methane, and others produced both gases or neither of them.
Six of the 24 participants produced methane, and of these six, three shown significant reduction after eating mango.
The researchers concluded that mangoes may be a heart-healthy fruit that may help play a role in reducing the risk of cardiovascular disease.
The research, which was supported in part by funds from the National Mango Board in the US, was presented at the American Society for Nutrition's annual meeting, Nutrition 2018, in Boston.